Characterizing mild cognitive impairment in Parkinson's disease
Identifieur interne : 000368 ( Main/Exploration ); précédent : 000367; suivant : 000369Characterizing mild cognitive impairment in Parkinson's disease
Auteurs : John C. Dalrymple-Alford [Nouvelle-Zélande] ; Leslie Livingston [Nouvelle-Zélande] ; Michael R. Macaskill [Nouvelle-Zélande] ; Charlotte Graham [Nouvelle-Zélande] ; Tracy R. Melzer [Nouvelle-Zélande] ; Richard J. Porter [Nouvelle-Zélande] ; Richard Watts [Nouvelle-Zélande] ; Tim J. Anderson [Nouvelle-Zélande]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-03.
English descriptors
Abstract
There is growing interest in identifying Parkinson's disease (PD) patients with mild cognitive impairment (PD‐MCI), but widely disparate criteria have been used. We assessed 143 PD patients and 50 matched controls on 20 measures across 4 cognitive domains (executive function, attention and working memory, learning and memory, visuoperception). Twenty‐four patients met criteria for dementia (PD‐D); nondementia patients were classified as either with normal cognition or MCI for 12 neuropsychological criteria. We compared the influence of these criteria on the distribution of global cognitive performance in the resulting PD‐MCI groups relative to the control and PD‐D groups. Different criteria produced substantial variation in the proportion of PD‐MCI cases identified. Fourteen percent PD‐MCI was found when using 2 scores in 1 domain at 2 standard deviations (SD) below normative scores, with no controls identified as MCI, through to 89% PD‐MCI with 1 score in 1 domain at 1 SD below normative scores, when 70% of controls were identified as MCI. The balance of cases with impaired cognition but not those with generally intact cognition was better served by using criteria that required 2 specific deficit scores or deficits across 2 domains. As comparisons with external normative data may have greater applicability across centers, we suggest that 2 scores at −1.5 SD within any single domain (30% PD‐MCI) or 1 score at −1.5 SD in each of 2 domains (37% PD‐MCI) provide suitable criteria to minimize the inclusion of cognitively well patients. Clinical dementia rating did not improve the relative identification of cognitively impaired and unimpaired nondementia PD patients. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23592
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-03">2011-03</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="629">629</biblScope><biblScope unit="page" to="636">636</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">AD8544816B0BAACC89B0859E85D9C46B7DFB2051</idno><idno type="DOI">10.1002/mds.23592</idno><idno type="ArticleID">MDS23592</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cognition</term><term>criteria</term><term>dementia</term><term>mild cognitive impairment</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is growing interest in identifying Parkinson's disease (PD) patients with mild cognitive impairment (PD‐MCI), but widely disparate criteria have been used. We assessed 143 PD patients and 50 matched controls on 20 measures across 4 cognitive domains (executive function, attention and working memory, learning and memory, visuoperception). Twenty‐four patients met criteria for dementia (PD‐D); nondementia patients were classified as either with normal cognition or MCI for 12 neuropsychological criteria. We compared the influence of these criteria on the distribution of global cognitive performance in the resulting PD‐MCI groups relative to the control and PD‐D groups. Different criteria produced substantial variation in the proportion of PD‐MCI cases identified. Fourteen percent PD‐MCI was found when using 2 scores in 1 domain at 2 standard deviations (SD) below normative scores, with no controls identified as MCI, through to 89% PD‐MCI with 1 score in 1 domain at 1 SD below normative scores, when 70% of controls were identified as MCI. The balance of cases with impaired cognition but not those with generally intact cognition was better served by using criteria that required 2 specific deficit scores or deficits across 2 domains. As comparisons with external normative data may have greater applicability across centers, we suggest that 2 scores at −1.5 SD within any single domain (30% PD‐MCI) or 1 score at −1.5 SD in each of 2 domains (37% PD‐MCI) provide suitable criteria to minimize the inclusion of cognitively well patients. Clinical dementia rating did not improve the relative identification of cognitively impaired and unimpaired nondementia PD patients. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Nouvelle-Zélande</li></country></list><tree><country name="Nouvelle-Zélande"><noRegion><name sortKey="Dalrymple Lford, John C" sort="Dalrymple Lford, John C" uniqKey="Dalrymple Lford J" first="John C." last="Dalrymple-Alford">John C. Dalrymple-Alford</name></noRegion><name sortKey="Anderson, Tim J" sort="Anderson, Tim J" uniqKey="Anderson T" first="Tim J." last="Anderson">Tim J. Anderson</name><name sortKey="Anderson, Tim J" sort="Anderson, Tim J" uniqKey="Anderson T" first="Tim J." last="Anderson">Tim J. Anderson</name><name sortKey="Anderson, Tim J" sort="Anderson, Tim J" uniqKey="Anderson T" first="Tim J." last="Anderson">Tim J. Anderson</name><name sortKey="Dalrymple Lford, John C" sort="Dalrymple Lford, John C" uniqKey="Dalrymple Lford J" first="John C." last="Dalrymple-Alford">John C. Dalrymple-Alford</name><name sortKey="Dalrymple Lford, John C" sort="Dalrymple Lford, John C" uniqKey="Dalrymple Lford J" first="John C." last="Dalrymple-Alford">John C. Dalrymple-Alford</name><name sortKey="Graham, Charlotte" sort="Graham, Charlotte" uniqKey="Graham C" first="Charlotte" last="Graham">Charlotte Graham</name><name sortKey="Graham, Charlotte" sort="Graham, Charlotte" uniqKey="Graham C" first="Charlotte" last="Graham">Charlotte Graham</name><name sortKey="Livingston, Leslie" sort="Livingston, Leslie" uniqKey="Livingston L" first="Leslie" last="Livingston">Leslie Livingston</name><name sortKey="Livingston, Leslie" sort="Livingston, Leslie" uniqKey="Livingston L" first="Leslie" last="Livingston">Leslie Livingston</name><name sortKey="Macaskill, Michael R" sort="Macaskill, Michael R" uniqKey="Macaskill M" first="Michael R." last="Macaskill">Michael R. Macaskill</name><name sortKey="Macaskill, Michael R" sort="Macaskill, Michael R" uniqKey="Macaskill M" first="Michael R." last="Macaskill">Michael R. Macaskill</name><name sortKey="Melzer, Tracy R" sort="Melzer, Tracy R" uniqKey="Melzer T" first="Tracy R." last="Melzer">Tracy R. Melzer</name><name sortKey="Melzer, Tracy R" sort="Melzer, Tracy R" uniqKey="Melzer T" first="Tracy R." last="Melzer">Tracy R. Melzer</name><name sortKey="Porter, Richard J" sort="Porter, Richard J" uniqKey="Porter R" first="Richard J." last="Porter">Richard J. Porter</name><name sortKey="Watts, Richard" sort="Watts, Richard" uniqKey="Watts R" first="Richard" last="Watts">Richard Watts</name><name sortKey="Watts, Richard" sort="Watts, Richard" uniqKey="Watts R" first="Richard" last="Watts">Richard Watts</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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